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eb design company & digital marketing agency focused on growing brands online.
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eb design company & digital marketing agency focused on growing brands online.
We create effective brand strategies, custom web design, development, and digital marketing solutions to generate greater brand engagement and conversions. We work closely with our clients to ensure each project meets their brand guidelines and business goals and provide technical and marketing expertise to ensure optimal results.
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eb design company & digital marketing agency focused on growing brands online.
We create effective brand strategies, custom web design, development, and digital marketing solutions to generate greater brand engagement and conversions. We work closely with our clients to ensure each project meets their brand guidelines and business goals and provide technical and marketing expertise to ensure optimal results.
Strategic content designed
Strategic content designed to drive measurable growth and conversions.
SEO and digital marketing insights
JAK activating mutations are a major molecular mechanism in malignant hematologic diseases. Researchers have identified a unique somatic mutation (V617F) in the Jak2 pseudokinase domain. This mutation, which often occurs in patients with true erythroblastosis, primary thrombocytosis and myelofibrosis, leads to pathological activation of Jak2, which also activates receptors for erythropoietin (EPO), thrombopoietin (TPO) and G-CSF that control the proliferation and differentiation of erythrocytes, megakaryocytes and granulocytes. The functionally acquired somatic mutation of Jak1 has been found in adult acute lymphoblastic leukemia.
Somatic activating mutations have been shown to be present in pediatric acute lymphoblastic leukemia (ALL) patients. In addition, mutations near the Jak2 pseudokinase domain R683 (R683G or ΔIREED) have been identified in children with Down syndrome B-ALL as well as in patients with pediatric Down syndrome.
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